The bigger the wheel, the more it weighs, and the more your performance is decreased -> That's simple rotational mechanics and properties of inertia. Certain wheel manufacturers build wheels which are incredibly strong while super lightweight... those are ideal, but cost an @ss-ton (but would allow you to run bigger wheels without the weight penalties).
"looking at all aspects such as performance wise"?
What purpose is your car supposed to serve? If you're thinking about going to the track and destroying all opposition... good luck. The SRT-4 can skool the AV6.
I think a lot of other AV6ers would agree that performance cannot be the only influence on your mod decisions... because in that case you're wasting your money. The AV6 is a sweet ride... but you could get oodles more performance out of a '94 240SX. And it would be a standard... AND it would be RWD.
Since you haven't really searched through the forums for answers for all these performance mods... have you searched and read about the transmission deficiencies? That might change your mind about turning your accord into a street racer